John Wayne Cancer Institute, Santa Monica, USA
Dave S.B. Hoon, Professor and Chief of Scientific Intelligence at the John Wayne Cancer Institute, interacts with external academic, industry, government agencies, and international cancer centers to develop innovative translational cancer research opportunities. He has coauthored more than 300 peer-reviewed articles and reviews, primarily related to translational molecular oncology of human solid tumors, and has over 25 patents on his studies. As founding Director of the Department of Molecular Oncology, Dr. Hoon continues to pioneer investigations of RNA/genomic/epigenomic biomarkers for diagnostic, prognostic and predictive assessment of residual tumor cells and tumor progression functions. Dr. Hoon spearheads investigations of circulating cell-free DNA/miRNA biomarkers for monitoring cancer in patients enrolled in phase II/III clinical trials. Dr. Hoon’s team has developed diagnostic tissue biomarkers for molecular staging of sentinel lymph nodes and classification of human solid tumors including breast cancer. In the last decade he and his team have developed programs for assessment of regulatory pathways of aggressive breast cancers such as TNBC. On the therapeutic front, Dr. Hoon is examining functional genomic and epigenomic changes as potential targets for development of novel approaches to treat breast cancer. He also works on new immunogenetic approaches of assessing solid tumors responses to cancer immunotherapy.